Looking for BPS3071 Nanotechnology and polymer science in drug delivery S1 2025 test answers and solutions? Browse our comprehensive collection of verified answers for BPS3071 Nanotechnology and polymer science in drug delivery S1 2025 at learning.monash.edu.
Get instant access to accurate answers and detailed explanations for your course questions. Our community-driven platform helps students succeed!
Which of the following statements about cyclodextrin are true?
How does combining surfactants with different HLB values facilitate the formation of smaller O/W nanoemulsion droplets?
If viscosity in continuous phase increase, so creaming...
A researcher aims to functionalize three types of nanoparticles – Gold Nanorods (AuNRs), Iron Oxide Nanoparticles (IONPs, bare surface after thermal decomposition), and Mesoporous Silica Nanoparticles (MSNPs) – with PEG for improved in vivo stability. Which combination of surface attachment chemistries is most appropriate and commonly used for each nanoparticle type, based on their inherent surface properties?
Two MSNP batches are loaded with a water-soluble drug via simple soaking (adsorption/diffusion). Batch 1 has uniform 3 nm pores and shows a type E hysteresis loop in its N₂ isotherm. Batch 2 has uniform 10 nm pores and shows a type A hysteresis loop. Assuming the surface chemistry is identical and loading primarily occurs within the pores, which batch would you predict to show a faster initial diffusion-controlled release rate in a sink condition, and why?
Choose only one statement with justification and explain why the other statements would not be appropriate (give one reason)
(a) Batch 1 (3 nm pores), because the smaller pores create a stronger capillary force, expelling the drug faster.(b) Batch 1 (3 nm pores), because the higher surface area-to-volume ratio within the smaller pores leads to faster drug detachment.(c) Batch 2 (10 nm pores), because the drug molecules experience less physical restriction (tortuosity) diffusing out of the wider channels.(d) Batch 2 (10 nm pores), because the larger volume allows for a higher concentration gradient to be established initially.
Cyclosporin A (CyA) was formulated using a combination of Span 80, Tween 80, and Cremophor RH 40 to spontaneously form a nanoemulsion upon mixing with water (25 nm particle size). This formulation achieved high bioavailability for CyA. How does this nanoemulsion primarily achieve stability compared to a thermodynamically stable microemulsion?
a) By achieving an extremely low interfacial tension through specific surfactant ratios, making it thermodynamically stable like a microemulsion.b) By relying solely on high zeta potential (> |30mV|) created by the phospholipid component for strong electrostatic repulsion.c) Through kinetic stability provided by a robust interfacial film formed by surfactants that significantly slows down Ostwald ripening and coalescence, despite being thermodynamically unstable.d) By using only high-energy preparation methods, which inherently create thermodynamically stable systems regardless of surfactant choice.
Choose only one statement with justification and explain why the other statements would not be appropriate (give one reason).
You are synthesizing MSNPs using CTAB as the surfactant template and TEOS as the silica source. You decide to add a small amount of a hydrophobic swelling agent (like TMB) to the reaction mixture while keeping all other parameters constant. What changes would you most likely observe in the final MSNPs' properties compared to MSNPs made without the swelling agent?
Considering the different mechanisms of action and limitations discussed for AuroLase® (AuNP PTT) and NanoTherm® (IONP MHT), which factor represents the intrinsic advantage of the MHT approach for treating deeply located brain tumours (like glioblastoma)?
DOXIL® (DOXorubicin In Liposomes) is an effective anti-cancer pharmaceutical product. Choose all the correct statements:
I have completed the pre-lab calculations and will show them to the TA at the start of the lab.
Get Unlimited Answers To Exam Questions - Install Crowdly Extension Now!