A researcher aims to functionalize three types of nanoparticles – Gold Nanorods (AuNRs), Iron Oxide Nanoparticles (IONPs, bare surface after thermal decomposition), and Mesoporous Silica Nanoparticles (MSNPs) – with PEG for improved in vivo stability. Which combination of surface attachment chemistries is most appropriate and commonly used for each nanoparticle type, based on their inherent surface properties?

Question

A researcher aims to functionalize three types of nanoparticles – Gold Nanorods (AuNRs), Iron Oxide Nanoparticles (IONPs, bare surface after thermal decomposition), and Mesoporous Silica Nanoparticles (MSNPs) – with PEG for improved  in vivo  stability. Which combination of surface attachment chemistries is  most appropriate  and commonly used for each nanoparticle type, based on their inherent surface properties?

Answer

AuNRs: Coordination chemistry; IONPs: Thiol chemistry; MSNPs: Silane chemistry.

Answer

AuNRs: Thiol chemistry (Au-S); IONPs: Coordination chemistry (e.g., phosphonates/carboxylates) or post-coating functionalization; MSNPs: Silane chemistry (Si-O-Si).

Answer

AuNRs: Silane chemistry; IONPs: Silane chemistry; MSNPs: Thiol chemistry.

Answer

AuNRs: Silane chemistry; IONPs: Thiol chemistry; MSNPs: Coordination chemistry (e.g., carboxylates).

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A researcher aims to functionalize three types of nanoparticles – Gold Nanorods ...

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