Two MSNP batches are loaded with a water-soluble drug via simple soaking (adsorp...
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Two MSNP batches are loaded with a water-soluble drug via simple soaking (adsorption/diffusion). Batch 1 has uniform 3 nm pores and shows a type E hysteresis loop in its N₂ isotherm. Batch 2 has uniform 10 nm pores and shows a type A hysteresis loop. Assuming the surface chemistry is identical and loading primarily occurs within the pores, which batch would you predict to show a faster initial diffusion-controlled release rate in a sink condition, and why?
Choose only one statement with justification and explain why the other statements would not be appropriate (give one reason)
(a) Batch 1 (3 nm pores), because the smaller pores create a stronger capillary force, expelling the drug faster.(b) Batch 1 (3 nm pores), because the higher surface area-to-volume ratio within the smaller pores leads to faster drug detachment.(c) Batch 2 (10 nm pores), because the drug molecules experience less physical restriction (tortuosity) diffusing out of the wider channels.(d) Batch 2 (10 nm pores), because the larger volume allows for a higher concentration gradient to be established initially.
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