It is made up of four different polypeptide chains with two complementary antigen binding sites

It is made up of two pairs of polypeptide chains with two identical antigen binding sites

It is made up of two polypeptide chains with two complementary antigen binding sites

It is made up of four identical polypeptide chains with two identical antigen binding sites

Degranulation of the activated cell

Upregulation of MHC molecules on the cell surface

Activation of caspase-1

Increased affinity of cell surface integrin

1: Eosinophil, 2: Lymphocyte, 3: Neutrophil, 4: Basophil

1: Neutrophil, 2: Lymphocyte, 3: Eosinophil, 4: Basophil

1: Neutrophil, 2: Macrophage, 3: Lymphocyte, 4: Basophil

1: Basophil, 2: Lymphocyte, 3: Basophil, 4: Neutrophil

Afferent lymphatics

Efferent lymphatics

Arterial blood flow

Venous blood flow

The constant region

The target antigen

The binding affinity

The variable region

Will display the invariant chain (Ii) from CLIP in the binding cleft

Will display self-peptides in the MHC binding cleft

Will not be transported to the surface of the cell

Will not display any peptides in the MHC binding cleft

They generate pro-IL-1

Each TLR can bind a broad range of PAMPs

The localisation of a TLR with the cell determines which PAMP it recognises

All TLRs are expressed on (or in) each innate immune cell

1: Neutrophil, 2: Lymphocyte, 3: Eosinophil, 4: Basophil

1: Neutrophil, 2: Macrophage, 3: Lymphocyte, 4: Basophil

1: Basophil, 2: Lymphocyte, 3: Basophil, 4: Neutrophil

1: Eosinophil, 2: Lymphocyte, 3: Neutrophil, 4: Macrophage

Provide structural support for these organs

Are the exit points for lymphoid cells to drain from the organ into the lymphatics

Are the site where the lymphoid cells enter the organ from the blood circulation

Act as a barrier to separate the T and B lymphocytes within these organs