Working as a genetic counsellor, you have constructed a pedigree based on the family history of a genetic trait. Unless told otherwise in a question, you are to assume full penetrance of the trait based on the genotype. Individuals with the trait are coloured in blue, those without the trait are white. The dominant version of the allele is B, while the recessive version is b.

Based on your analysis of the pedigree, what is the most likely mode of inheritance:

---

Given the most likely mode of inheritance, determine the genotype of the following individuals, using the following rules (answers are case sensitive):

• If autosomal use B (dominant) and b (recessive)

• If X-linked use XB (dominant), Xb (recessive) and Y

• If Y-linked use X, YB (affected) and Yb (unaffected)

• Dominant versions of the allele come before recessive ones (Bb NOT bB, XBXb NOT XbXB)

• If sex linked, X chromosomes come before Y chromosomes (XBY NOT YXB, XYb not YbX)

• No spaces should be placed between alleles.

Person B:

Person C:

Person D:

Person E:

---

Person C and person D are looking to have another child. What is the chance:

They have a child with have the trait: 

% (enter a number only, e.g. 1 NOT one, do not include the percentage sign)

If they have a daughter, their daughter will have the trait: 

% (enter a number only, e.g. 1 NOT one, do not include the percentage sign)

---

Previously you assumed 100% penetrance. If the people in the above pedigree had the same genotypes, however the trait instead had a penetrance of 25%, how many people with the trait would you expect in the pedigree?

people with the trait (enter a number only, e.g. 1 NOT one)