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YEAR-1 Course management

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A new diagnostic test provides fast, simple, and cheap detection of HCV infection. In a sample of 500 people, only 35 are confirmed to have HCV infection using the gold standard PCR test.

Using the following results, calculate the sensitivity of the test.

 

Condition (HCV infection)

YES

NO

Total

New diagnostic test results

+ve

30

15

45

-ve

5

450

455

Total

35

465

500

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A 2 days-old male infant is born with herniation of intestine into umbilicus. Prenatal ultrasound scans during the pregnancy showed an abnormality of the anterior abdominal wall, which was suspected to be an omphalocele. At which week of development does failure of return of the intestinal lobe typically occur in this baby?

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Mr. Ahmed has a peptic ulcer. His physician prescribes a drug that inhibits gastric acid secretion by blocking H2-recpetors. Which of the following drug is most likely prescribed?

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A 10-year old boy has muscle weakness. Genetic testing reveals a mutation in Carnitine acyl transferase II (CAT II) gene and he is diagnosed with CAT II deficiency. Which single product arises from the reaction catalyzed by this enzyme?

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A 35-year-old woman presents with flatulence, bloating, and steatorrhea. Normally, dietary triacylglycerol is hydrolyzed in the intestine into components that can be easily absorbed. Which enzyme is most likely deficient in this case?

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A 48-year-old man is admitted to the hospital with severe abdominal pain. Radiographic examination reveals a tumor in the tail of the pancreas. A diagnostic arteriogram shows that the tumor has compromised the blood supply to another organ. Which organ is most likely to have its blood supply compromised by this tumor?

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A patient with severe hypertension is being treated with furosemide. What is the mechanism of action of this drug?

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A 57 year old man is brought to the ED with difficult swallowing. Imaging reveals injury of the swallowing afferent nerve fibers.

Which cranial nerve is most likely injured?

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An 8-year-old girl has early puberty and short stature. She is treated with an allosteric modifier. Which is the most likely mechanism of allosteric regulation in this case?

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A researcher wants to measure the extracellular fluid (ECF) volume for a group of adult men.

What is the most likely substance would he use?

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