Which of the following would be a presenting symptom in an

infant born with dysfunction of the structures in the

photomicrograph?

A 19-year-old student

comes to the eye clinic with a very common problem today. He suffers from

cutting and burning eyes, the feeling of a foreign body in the eye, pressure,

and the feeling of tired eyes. The eyes are red. He is diagnosed with dry eye

syndrome. This can have many causes, and one of them is low tear production,

for example, as a result of taking certain medications. Tears are produced by

the lacrimal gland. The lacrimal gland is an exocrine gland. Its cells have a

basophilic cytoplasm and a round nucleus located in the basal third of the

cell. The basal part of the cells shows significant basophilia due to the

accumulation of polyribosomes and granular endoplasmic reticulum for the

production of proteins that are part of the produced secretion. The cells

contain zymogen granules, which are mostly released in a merocrine manner. What

type of gland is a lacrimal gland?

During a routine preventive examination, a

65-year-old patient is found to have an asymmetrically enlarged liver. The

patient himself admits that he drinks alcohol regularly and is therefore

referred for an ultrasound examination of the liver. The examination reveals a

prominent mass in the right lobe of the liver and a biopsy shows hepatocellular

carcinoma. After further investigations, the patient undergoes surgery during

which the tumour is removed. To confirm that the entire tumour has been

removed, including a sufficient margin of surrounding healthy liver tissue, the

resection is sent to pathology. What epithelium makes up the rim of healthy

liver tissue?

An 18-year-old female patient

is coming to the emergency office of the Department of Ophthalmology. She is

suffering from significant swelling of the upper eyelid. The eyelid is markedly

swollen, stiff and reddened in one spot. The eyelid is painful and causes

significant tearing of the entire eye. After examination of the eyelid, the

doctor concludes that it is a chalazion (eyelid cyst or Meibomian cyst). It is

an inflammation of the Meibomian gland of the eyelid, which can be seen in the

picture. What type of gland is it with regard to the mechanism of secretion?

A 17-year-old female patient has gradually developed symptoms such as fatigue, weakness, dyspnea on exertion and impaired

performance over several months. These symptoms gradually worsen over the last

year or so. She now comes for intense right hip pain. On further questioning,

she indicates frequent epistaxis (nosebleeds) and easy development of bruises.

During the physical examination, the physician notes striking pallor of the

skin and mucous membranes, tachycardia as well as hepatomegaly (enlargement of the

liver) and splenomegaly (enlargement of the spleen). Laboratory findings

confirm the presence of anemia and thrombocytopenia. A special finding is the

picture of the so-called Erlenmeyer flask deformity of the diaphyses of the

femurs. This sign is already suggestive to the physicians and the determination

of low activity of the enzyme β-glucocerebrosidase in isolated leukocytes

confirms the diagnosis of Gaucher disease. Gaucher disease is an inherited

lysosomal storage disease that is caused by a genetic defect in the lysosomal

enzyme glucocerebrosidase. This enzyme is responsible for the hydrolytic

cleavage of glucosylceramide to glucose and ceramide. What is the function of

lysosomes? What will their failure lead to in the cell?

How can I reach my teacher?

What happens if I do not pass one of the three tests in Moodle?

How many reading guides do I need to complete for my credit?

What can I do to receive the 100 points necessary for the credit (more than one answer might be correct)?