They found that the timing of nuclear transfer, before or after fertilization, significantly impacts the success of meiotic-spindle transfer

They concluded that pronuclear transfer is more effective than meiotic-spindle transfer in eliminating mutant mtDNA from embryos

They suggested that meiotic-spindle transfer is ineffective in eliminating mutant mtDNA from embryos and requires further investigation

They successfully produced blastocyst-stage embryos with negligible amounts of mutant mtDNA using meiotic-spindle transfer