Schizophrenia is associated with positive, negative and cognitive symptoms. Define each domain of symptoms including at least one specific example of how each might manifest in an individual and the underlying pathophysiology thought to be involved in each domain of symptoms.

Pharmacotherapies exist to treat the positive and negative symptom domains of schizophrenia however there is still a need to advance novel drug treatments for Schizophrenia. Discuss TWO major contributors (covered during class discussion) that might impede the progress of a future drug candidate for the treatment of schizophrenia in the area of neuroscience drug discovery.

[8 marks, 10 minutes]