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You are a clinician explaining Alzheimer’s disease progression to a patient’s family member. Using plain language, describe what happens to the brain structurally and chemically in AD and how this explains the patient’s:
Memory
loss
Difficulty
with speech or language
Confusion
and personality changes
Your response should explain links between brain region damage (e.g. hippocampus, cortex), cholinergic deficits, and hallmark pathology (plaques and tangles).
[8 marks, 10 minutes]
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