GLUT1 facilitates the transport of glucose from the outside to the inside of red blood cells, down the concentration gradient of glucose.
The mechanism of GLUT1 action is shown below, along with a graph showing the relationship between the extracellular concentration of glucose and the initial velocity (rate) of glucose entry facilitated by GLUT1. Note the similarity of this graph to a Michaelis-Menten curve.

Which of the following factors is most likely to control the maximum rate of facilitated diffusion (i.e., the value of V max ) for this facilitated transport process?
[Note: You may need to draw on your understanding of Michaelis-Menten kinetics to answer this question]

Question

GLUT1 facilitates the transport of glucose from the outside to the inside of red blood cells, down the concentration gradient of glucose. 
 The mechanism of GLUT1 action is shown below, along with a graph showing the relationship between the extracellular concentration of glucose and the initial velocity (rate) of glucose entry facilitated by GLUT1. Note the similarity of this graph to a Michaelis-Menten curve.

Which of the following factors  is most likely to control the  maximum rate of facilitated diffusion  (i.e., the value of  V max ) for this facilitated transport process? 
 [Note: You may need to draw on your understanding of Michaelis-Menten kinetics to answer this question]

Answer

The strength of binding between glucose and the T 2  state of GLUT1

Answer

The rate of binding between glucose and the T 1  state of GLUT1

Answer

The rate of interconversion between the T 1  and T 2  states of GLUT1 bound to glucose

Answer

The strength of binding between glucose and the T 1  state of GLUT1

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