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Drug A is an active anti-epileptic drug with pharmacokinetic parameters shown in...

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Drug A is an active anti-epileptic drug with pharmacokinetic parameters shown in the table below. 

Pharmacokinetic analysis of Drug A taken in combination with a herbal supplement (extract A) was performed and tabulated as shown above.

Extract A is MOST LIKELY altering the pharmacokinetics of Drug A by which one of the following mechanisms?

 

 

What is the MOST LIKELY clinical consequence of taking Drug A with this herbal extract?

 

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