Explain the mechanism of action of memantine and indicate why it may be prescribed in Alzheimer’s disease; what is the physiological rationale for use?

Describe the changes in the brain of a patient with Alzheimer’s disease, with regards to cholinergic transmission. Explain the mechanism of action of anticholinesterases and indicate why they may be prescribed in Alzheimer’s disease; what is their physiological rationale for use?

Explain the role of cholinergic transmission in learning and memory.

Explain the role of glutamatergic signalling in learning and memory. In your answer indicate the role of AMPA and NMDA receptors, and describe the resultant changes in synaptic plasticity. What physical changes within the dendrites of a neurone may occur to engender or promote longer-term changes in synaptic architecture?

Describe the hallmark pathological signs of Alzheimer’s disease, and link these to the outcomes in terms of neuronal health or function.

List the symptoms of Alzheimer’s disease and relate these symptoms to damage in different brain regions. Make sure you can define the terminology relating to the key symptoms, but also use 'real world' examples to demonstrate your understanding of how these symptoms manifest in a patient.